Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/12116
Título: | Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon. |
Autor(es): | Melo, Luísa Helena Perin de Fonseca, Kátia da Silva Carvalho, Thaís Vieira de Carvalho, Lívia Mendes Madeira, João Vitor Medeiros, Luciana da Fonseca Molina, Israel Oliveira, Rodrigo Corrêa de Carneiro, Cláudia Martins Vieira, Paula Melo de Abreu |
Palavras-chave: | Trypanosoma cruzi Treatment |
Data do documento: | 2020 |
Referência: | MELO, L. H. P. et al. Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon. Experimental Parasitology, v. 210, p. 107834, mar. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S001448941930503X?via%3Dihub>. Acesso em: 10 fev. 2020. |
Resumo: | Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg/day) is similarly effective as the usual dose in the chronic mice model (100% of cure). In addition, the treatment in the chronic model of Chagas' disease presented better results than the acute model and colon appears to be a key tissue when it comes to evaluating treatment efficacy compared to blood and heart. Therefore, our data suggest the reconsideration of the current therapy, mainly in the chronic phase of the disease. |
URI: | http://www.repositorio.ufop.br/handle/123456789/12116 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S001448941930503X?via%3Dihub |
DOI: | https://doi.org/10.1016/j.exppara.2020.107834 |
ISSN: | 0902-449 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_LowDoseBenznidazole.pdf Restricted Access | 351,41 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.