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http://www.repositorio.ufop.br/jspui/handle/123456789/11973
Título: | Intranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice. |
Autor(es): | Fróes, Sophia Dias Pozzolini Souza, Ana Beatriz Farias de Matos, Natália Alves de Philips, Nicole Elizabeth Costa, Guilherme de Paula Silva, André Talvani Pedrosa da Cangussú, Silvia Dantas Bezerra, Frank Silva |
Data do documento: | 2019 |
Referência: | FRÓES, S. D. P. et al. Intranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice. Respiratory physiology & neurobiology, v. 266, p. 27-32, ago. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1569904819300667?via%3Dihub>. Acesso em: 10 fev. 2020. |
Resumo: | Bronchial obstruction, caused by retained secretions, is often treated by the administration of mucoactive agentes including distilled water, saline, hypertonic saline, and sodium bicarbonate. However, the inflammatory effect of these solutions on the lungs remains unclear. This study evaluated the instillation effects of different solutions on oxidative stress and lung inflammatory response in C57BL/6 mice. Fifty C57BL/6 mice were divided into 5 groups: control (CG); distilled water (DWG), hypertonic saline (HSG), saline (SG) and sodium bicarbonate (SBG). CG was exposed to ambient air while DWG, HSG, SG and SBG had 50 μl of respective solutions administered intranasally for 5 consecutive days. Twenty-four hours after the last intranasal instillation, all animals were euthanized for subsequent analysis. All solutions promoted increased recruitment of inflammatory cells to the lung compared to controls. Superoxide dismutase activity was lower in HSG compared to all other groups; catalase activity was reduced in SG, while it increased in SBG and DWG compared to CG. Finally, there was na increase in the inflammatory markers TNF-α, CCL2 and IFN-γ in DWG compared to CG, SG and HSG. In conclusions, the intranasal instillation of different solutions promotes redox imbalance and inflammation on lungs of adult mice. |
URI: | http://www.repositorio.ufop.br/handle/123456789/11973 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S1569904819300667?via%3Dihub |
DOI: | https://doi.org/10.1016/j.resp.2019.04.013 |
ISSN: | 1569-9048 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_IntranasalInstillationDistilled.pdf Restricted Access | 813,77 kB | Adobe PDF | Visualizar/Abrir |
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