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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Lacerda, Débora Romualdo | - |
dc.contributor.author | Soares, Danusa Dias | - |
dc.contributor.author | Costa, Kátia Anunciação | - |
dc.contributor.author | Silva, Albená Nunes da | - |
dc.contributor.author | Rodrigues, Débora Fernandes | - |
dc.contributor.author | Sabino, Josiana Lopes | - |
dc.contributor.author | Silveira, Ana Letícia Malheiros | - |
dc.contributor.author | Pinho, Vanessa | - |
dc.contributor.author | Vieira, Érica Leandro Marciano | - |
dc.contributor.author | Menezes, Gustavo Batista | - |
dc.contributor.author | Antunes, Maísa Mota | - |
dc.contributor.author | Teixeira, Mauro Martins | - |
dc.contributor.author | Ferreira, Adaliene Versiani Matos | - |
dc.date.accessioned | 2020-03-05T12:48:24Z | - |
dc.date.available | 2020-03-05T12:48:24Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | LACERDA, D. R. et al. Mechanisms underlying fat pad remodeling induced by fasting: role of PAF receptor. Nutrition, n. 7, p. 110616, mar. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0899900719301996?via%3Dihub>. Acesso em: 10 fev. 2020. | pt_BR |
dc.identifier.issn | 0899-9007 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11960 | - |
dc.description.abstract | Objectives: Fasting has long been practiced for political and religious reasons and to lose weight. However, biological responses during fasting have yet to be fully understood. Previous studies have shown that cytokines may control fat pad expansion, at least in part, owing to the induction of lipolysis. Indeed, we have previously shown that mice with a lower inflammatory response, such as platelet-activating factor receptor knockout mice (PAFR / ), are prone to gain weight and adiposity. The aims of this study were to determine whether adipose tissue becomes inflamed after fasting and to evaluate whether the PAF signaling is a fator in the fat loss induced by fasting. Methods: Wild-type (WT) and PAFR / mice were fasted for 24 h. Adiposity, leukocyte recruitment, and cytokine levels were evaluated. Multiple comparisons were performed using two-way analysis of variance and post hoc Fisher exact test. Results: After fasting, male WT mice showed lower adiposity (P < 0.001), higher recruitment of immune cells (P < 0.001), and increased cytokine levels (P < 0.05) in adipose tissue. Although WT mice lost ~79% of their adipose tissue mass, PAFR / mice lost only 36%. Additionally, PAFR / mice did not show enhanced cytokine and chemokine levels after fasting (P > 0.05). Conclusion: Despite low-grade inflammation being associated with metabolic syndrome, at least in part, the inflammatory milieu is also important to induce proper fat mobilization and remodeling of adipose tissue. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | IL- 6 | pt_BR |
dc.subject | TNF- a | pt_BR |
dc.subject | Fat loss | pt_BR |
dc.title | Mechanisms underlying fat pad remodeling induced by fasting : role of PAF receptor. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/pii/S0899900719301996?via%3Dihub | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.nut.2019.110616 | pt_BR |
Aparece nas coleções: | DEEFD - Artigos publicados em periódicos |
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ARTIGO_MechanismUnderlyingPad.pdf Restricted Access | 1,88 MB | Adobe PDF | Visualizar/Abrir |
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