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Title: Anti-Inflammatory and antioxidant properties of black mulberry (Morus nigra L.) in a model of LPS-induced sepsis.
Authors: Lúcio, Karine de Pádua
Rabelo, Ana Carolina Silveira
Araújo, Carolina Morais
Brandão, Geraldo Célio
Souza, Gustavo Henrique Bianco de
Silva, Regislainy Gomes da
Souza, Débora Maria Soares de
Silva, André Talvani Pedrosa da
Bezerra, Frank Silva
Calsavara, Allan Jefferson Cruz
Costa, Daniela Caldeira
Issue Date: 2018
Citation: LÚCIO, K. de P. et al. Anti-Inflammatory and antioxidant properties of black mulberry (Morus nigra L.) in a model of LPS-induced sepsis. Oxidative Medicine and Cellular Longevity, v. 2018, p. 1-14, 2018. Disponível em: <>. Acesso em: 22 fev. 2019.
Abstract: Sepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Thus, more studies have been carried out to investigate the therapeutic potential of plants such as Morus nigra L., popularly known as black mulberry. Studies have shown that plants belonging to the Morus genus are rich in secondary metabolites such as flavonoids which are associated with important biological activities as antioxidant and anti-inflammatory actions. Based on this context, the objective of our study was to evaluate the anti-inflammatory and antioxidant properties of Morus nigra L. in a sepsis model induced by LPS. Male C57BL/6 mice were distributed in four groups: control, sepsis, sepsis treated with leaf extract of mulberry, and sepsis treated with mulberry pulp. The animals were treated with 100 μL of their respective treatments for twenty-one days. Sepsis was induced at the 21st day with lipopolysaccharide (LPS) by intraperitoneal injection. The animals were euthanized 24 hours after receiving the LPS injection. The data obtained were analyzed in GraphPad Prism 6.0 software. Our results showed that treatment with either extract significantly decreased the number of leukocytes in the bronchoalveolar lavage fluid and serum levels of TNF in septic animals. Regarding the redox status, the treatments significantly decreased the antioxidant activity of the enzyme glutathione peroxidase. Regarding metalloproteinase type 2, it was observed that the treatment with black mulberry pulp was able to significantly reduce the activity of this enzyme concerning the sepsis group. Finally, these results together promoted an increase in the animal’s survival that received the black mulberry leaf or pulp extract.
ISSN: 19420994
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: O próprio artigo.
Appears in Collections:DECBI - Artigos publicados em periódicos

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