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Title: Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity.
Authors: Rabelo, Ana Carolina Silveira
Araújo, Glaucy Rodrigues de
Lúcio, Karine de Pádua
Araújo, Carolina Morais
Miranda, Pedro Henrique de Amorim
Silva, Breno de Mello
Carneiro, Ana Cláudia Alvarenga
Ribeiro, Erica Milena de Castro
Lima, Wanderson Geraldo de
Souza, Gustavo Henrique Bianco de
Brandão, Geraldo Célio
Costa, Daniela Caldeira
Keywords: Ethanol
Redox imbalance
Issue Date: 2017
Citation: RABELO, A. C. S. et al. Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity. Revista Brasileira de Farmacognosia, v. 27, n. 6, p. 729-738, nov./dez. 2017. Disponível em: <>. Acesso em: 22 fev. 2019.
Abstract: The metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of Baccharis trimera (Less.) DC., Asteraceae, in a model of hepatotoxicity induced by ethanol. The extract was characterized and in vitro tests were conducted in HepG2 cells. It was evaluated the cells viability exposed to aqueous extract for 24 h, ability to scavenging the radical DPPH, besides the production of reactive oxygen species and nitric oxide, and the influence on the transcriptional activity of transcription factor Nrf2 (12 and 24 h) after exposure to 200 mM ethanol. The results showed that aqueous extract was non-cytotoxic in any concentration tested; moreover, it was observed a decrease in ROS and NO production, also promoting the transcriptional activity of Nrf2. In vivo, we pretreatment male rats Fisher with 600 mg/kg of aqueous extract and 1 h later 5 ml/kg of absolute ethanol was administrated. After two days of treatment, the animals were euthanized and lipid profile, hepatic and renal functions, antioxidant status and oxidative damage were evaluated. The treatment with extract improved liver function and lipid profile, reflecting the reduction of lipid microvesicules in the liver. It also promoted an increase of glutathione peroxidase activity, decrease of oxidative damage and MMP2 activity. These results, analyzed together, suggest the hepatoprotective effect of B. trimera aqueous extract.
ISSN: 0102695X
metadata.dc.rights.license: This is an open access article under the CC BY-NC-ND license ( Fonte: o próprio artigo
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