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Title: The overweight increases circulating inflammatory mediators commonly associated with obesity in young individuals.
Authors: Lopes, Laís Roquete
Ribeiro, Silvana Mara Luz Turbino
Figueiredo, Vivian Paulino
Leite, Ana Luísa Junqueira
Nicolato, Roney Luiz de Carvalho
Estanislau, Juliana de Assis Silva Gomes
Oliveira, Fernando Luiz Pereira de
Silva, André Talvani Pedrosa da
Keywords: Obesity
Inflammatory biomarkers
Issue Date: 2018
Citation: LOPES, L. R. et al. The overweight increases circulating inflammatory mediators commonly associated with obesity in young individuals. Cytokine, v. 110, p. 169-173, out. 2018. Disponível em: <>. Acesso em: 22 fev. 2019.
Abstract: Obesity is a serious and growing world healthy problem affecting developed and developing countries. The new conception of obesity as a basal inflammatory condition has opened a new window of possibilities to identify inflammatory biomarkers to be used in the diagnosis or prognosis of obesity-associated comorbidities. This present work aims the identification of the adipokines (leptin and resistin), chemokines (CCL2, CCL5, CXCL16) and the BMP-2 and their association with the clinical, biochemical (fasting glucose, hemogram, cholesterol, T3, T4 and TSH) and anthropometric (weight, height, body circumferences, skinfold thickness and percentage of body fat) parameters in young adults (18–30 years old) presenting obesity and overweight. Our data showed increasing in anthropometric parameters and in the plasma inflammatory levels in those individuals presenting overweight and obesity. We observed a higher plasma levels of CCL2, CCL5, CXCL16, leptin and resistin in those overweigh and obese individuals. In addition, the CCL2, CCL5 presented a positive correlation with the body mass index and the body fat percentage. Assuming the obesity as a systemic inflammatory process, in this current study, the overweight individuals possess a close similar pattern of circulating inflammatory mediators which might be a potential risk of the development of obesity comorbidities. Further studies are still needed to precise the role of the biomarkers CCL2, CCL5, CXCL16 and BMP-2 in the clinical prognosis related to the overweight or obese individuals.
ISSN:  10434666
Appears in Collections:DECBI - Artigos publicados em periódicos

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