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Title: Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species.
Authors: Guzzo, Luciana Souza
Guimarães, Dênia Antunes Saúde
Silva, Adriana Carneiro
Lombardi, Júlio Antônio
Guimarães, Homero Nogueira
Guimarães, Andrea Grabe
Keywords: Writhing test
Hot-plate test
Issue Date: 2008
Citation: GUZZO, L. S. et al. Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species. Journal of Ethnopharmacology, v. 116, n. 1, p. 120-124, fev. 2008. Disponível em: <>. Acesso em: 10 jul. 2012.
Abstract: Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras.
ISSN: 03788741
metadata.dc.rights.license: O periódico Journal of Ethnopharmacology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 494627212.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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