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Title: Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats.
Authors: Maciel, Naira Rezende
Reis, Priscila Gomes dos
Kato, Kelly Cristina
Vidal, Alessandra Teixeira
Guimarães, Homero Nogueira
Frezard, Frederic Jean Georges
Barcellos, Neila Marcia Silva
Guimarães, Andrea Grabe
Keywords: Arterial pressure
Antimonial tartrate
Long-circulating liposomes
Issue Date: 2010
Citation: MACIEL, N. R. et al. Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats. Toxicology Letters, v. 199, n. 3, p. 234-238, dez. 2010. Disponível em: <>. Acesso em: 10 jul. 2012.
Abstract: Trivalent antimonial drugs, including tartar emetic (TA), are known to induce important cardiotoxicity observed by electrocardiographic abnormalities. Liposome encapsulation was found to reduce the overall acute toxicity of TA. The present work investigated the cardiovascular parameters alterations of rats submitted to the treatment with free and encapsulated TA in long-circulating liposomes. Liposomes were made using lipids DSPC, DSPE-PEG and cholesterol. The cardiovascular signals, electrocardiogram (ECG) and arterial blood pressure (AP), were recorded from anaesthetized Wistar rats after intravenous (IV) administration of a single specially high dose (17 mg/kg) of TA in liposomes and in free form. The IV administration of TA solution caused significant increase of QT interval of ECG and significant reduction of AP when compared to the control group. These alterations were not observed when liposomes TA were administered and the profile of ECG and AP data was quite similar to the control groups. In conclusion, a liposomal formulation of TA showed a reduced cardiotoxic profile for TA when compared to the free form.
ISSN: 03784274
metadata.dc.rights.license: O periódico Toxicology Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285430049485.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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