Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/10348
Title: Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension.
Authors: Locatelli, Jamille
Paiva, Nívia Carolina Nogueira de
Carvalho, Sara H. R.
Lavorato, Victor Neiva
Gomes, Luis Henrique Lobo Silame
Castro, Quênia Janaína Tomaz de
Guimarães, Andrea Grabe
Carneiro, Cláudia Martins
Natali, Antônio José
Isoldi, Mauro César
Keywords: Cardiac remodeling
Spontaneously hypertensive rats
Cardiomyocytes
Issue Date: 2017
Citation: LOCATELLI, J. et al. Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension. Life Sciences, v. 187, p. 42-49, out. 2017. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0024320517303983?via%3Dihub>. Acesso em: 05 abr. 2018
Abstract: Aim: Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Main methods: Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Key findings: Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Significance: Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR.
URI: http://www.repositorio.ufop.br/handle/123456789/10348
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S0024320517303983?via%3Dihub#!
ISSN:  00243205
Appears in Collections:DECBI - Artigos publicados em periódicos

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